Cell experiments, animal experiments, clinical research
In view of the fact that miRNA can be secreted by cells in a certain part of the body and go to other organs to function through the circulatory system, we can use this feature for drug delivery or treatment. In addition , the expression profiles of circulating miRNAs are different in different physiological and pathological states. According to this principle, we can use circulating miRNAs for disease diagnosis, treatment effect evaluation and disease prognosis judgment.
Experimentally proven: MIR-2911 directly inhibits the replication of the following viruses
Ten influenza viruses (in cooperation with Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences)
Ebola virus (in collaboration with the School of Basic Medicine, Union Medical College)
African swine fever virus (in collaboration with Cambridge University School of Medicine)
Yellow fever virus, Japanese encephalitis virus (in cooperation with Air Force Military Medical University)
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Core technologies
Original discovery 1: It is found that extracellular miRNA can exist completely and stably, and the source of extracellular miRNA and its stabilization mechanism are explained, breaking through the traditional concept of "RNA is unstable in the extracellular environment". For the first time, it was found that the expression profile of circulating miRNA in serum can accurately reflect the characteristics and development stages of different diseases, and it was proposed that circulating miRNA could be used as a new type of signal molecule for disease diagnosis, which established the principle of miRNA detection technology.
Original discovery 2: Discovery of miRNA cellular secretion mechanism
(1) The encapsulation of circulating miRNAs by vesicles such as exosomes is the molecular basis for their stable extracellular existence.
(2) Secreted miRNAs are transported between cells through microvesicles to mediate communication
(3) Secreted miRNAs constitute a new three-dimensional signaling network that regulates various life activities.
Original discovery 3: It was found that plant miRNAs regulate animal gene expression through absorption across borders, and further revealed the complete mechanism of miRNAs oral absorption into the human body.
Research results
The MIR2911 present in honeysuckle has an inhibitory effect on 94% of the 4,780 known viruses, including the new coronavirus. This provides a way for the scientific study of traditional Chinese medicine and pharmacology of traditional Chinese medicine, and also provides a theoretical basis for the modernization of traditional Chinese medicine.
Theoretically, miRNA can be used to treat any disease caused by abnormal gene expression. Symptomatic treatment drugs can be developed for diseases that can be diagnosed by serum miRNA, and the detection and drug treatment can truly be matched one-to-one.
MIR-2911 nucleic acid drug (green channel can be declared), MIR2911 has binding sites on 94% of the known 4780 viruses; cell-level or animal-level experiments have also proved that MIR2911 is in the new coronavirus, Ebola Viruses, Zika virus, African swine fever virus, Middle East respiratory fever virus, and porcine rotavirus have binding sites in their genomes that can inhibit the replication of these viruses.
future plan
PLAS-MIR2911 is conducting preclinical drug studies and is expected to be completed in May 2022.
(Cooperation with Taizhou China Medical City Jiangsu Mingma and Hetai Company)
To sum up, through more than ten years of research, from original discovery to mechanism demonstration, from theoretical system establishment to application practice, the Lifecode team has solved the problem that the current disease cannot be detected in the early stage, and solved the known target at the protein level. It solves the problem of difficult drug-making, solves the problem of nucleic acid drug delivery, and solves the problem of long time and high cost of new drug research and development. The miRNA root technology mother platform established by Lifecode will develop into an industrial development platform in various fields such as detection, pharmaceuticals, Chinese medicine development, animal husbandry, agriculture, national biosecurity, diagnosis and treatment big data, etc., to build a complete medical ecology and form miRNA The industrial cluster will become a global leader in the miRNA field in the future.
Urgent need to develop new antiviral drugs
Lack of broad-spectrum antiviral drugs
many side effects
expensive
ineffective treatment
susceptible to resistance
virus mutation
